NAD² (Nicotinamide Adenine Dinucleotide) is an essential coenzyme involved in mitochondrial energy production, redox cycling, cell-repair pathways and sirtuin activation. In controlled laboratory environments, NAD² is widely used to model mitochondrial efficiency, ATP-production pathways, oxidative-stress response, sirtuin (SIRT1, SIRT3) activity, DNA-repair mechanisms and cellular ageing or metabolic resilience.
This configuration provides 1000 mg) of NAD² pre-loaded into The Clinic 2mL / 200-click pen system, designed for high-precision micro-dosing and fine-grained research protocols.
Mechanism of Action
NAD² participates in several fundamental cellular processes:
- Electron transport chain: Supports mitochondrial respiration and ATP production.
- Sirtuin activation: Influences metabolic regulation, mitochondrial turnover and gene expression.
- DNA repair: Acts as a substrate for PARP-dependent repair pathways.
- Redox balance: Buffers oxidative stress via NAD²/NADH cycling.
- Energy metabolism: Central to cellular ATP generation and utilisation.
Key Themes
- Mapping mitochondrial performance under metabolic or oxidative stress.
- Investigating age-related NAD² depletion and restoration strategies.
- Studying oxidative injury and toxin-exposure resilience.
- Evaluating DNA stability and PARP-driven repair signalling.
- Exploring metabolic adaptations in nutrient-deficit and high-demand models.
All findings are model-specific and are presented purely as research context, not as therapeutic claims.
Dosage Protocol — Pen System (Research Context)
The Clinic standardises all cartridges to simplify research use and ensure reproducible dosing.
- Pen volume: 2 mL
- Total clicks per pen: 200 clicks
- NAD² content per pen: 1000 mg
- Strength: 1000 mg ÷ 200 clicks = 5 mg per click
- Reference points: 10 clicks = 50 mg, 20 clicks = 100 mg, 40 clicks = 200 mg, 100 clicks = 500 mg
This configuration meets The Clinic requirement of a minimum mid-point dose of at least 10 clicks.
Mitochondrial Function / Redox Model
| Phase | Reference Dose | Clicks per Event | Notes |
|---|---|---|---|
| Baseline (Days 1–3) | 50 mg | 10 clicks | Initial mitochondrial mapping and tolerance check |
| Standard Phase (Days 4–14) | 100 mg | 20 clicks | Core oxidative-phosphorylation and ATP-modelling |
| Extended Phase (Days 15–30) | 200 mg | 40 clicks | Higher-exposure metabolic stress testing |
DNA-Repair / PARP-Activation Model
| Timing | Reference Dose | Clicks per Event | Notes |
|---|---|---|---|
| Once Daily | 100–200 mg | 20–40 clicks | DNA-repair and PARP-signalling models |
| BID (optional) | 50 mg | 10 clicks | Continuous oxidative-stress or toxin-exposure frameworks |
All dosing values above are illustrative research examples only and must be tailored to the specific model, ethics approvals and study design. They are not prescribing guidance or therapeutic instructions.
Frequency & Cycle Length
- Frequency: Daily use is common in ATP and mitochondrial-function studies; twice-daily exposure may be used in redox-stress or toxin models.
- Cycle length: Mitochondrial-function studies often run 2–4 weeks; ageing/repair and oxidative-stress pathways may extend to 4–8 weeks.
Expected Outcomes
In preclinical and cellular models, NAD² exposure has been associated with:
- Increased cellular NAD² pool availability.
- Enhanced mitochondrial efficiency and ATP output.
- Improved resilience to oxidative and metabolic stress.
- Activation of sirtuin-mediated metabolic and longevity pathways.
- Support of DNA-repair processes and genomic-stability signalling.
- Reduced inflammatory and oxidative markers in specific models.
These findings are research observations only and must not be interpreted as therapeutic promises or guaranteed outcomes.
Product Details & Cartridge Summary
Product Information
- Compound: NAD² (Nicotinamide Adenine Dinucleotide)
- Content: 1 mg (1000 mg) per 2 mL pen
- Concentration: 5 mg per click (200 clicks total)
- Form: Pre-loaded research pen cartridge
What’s in the Box
- 1 × NAD+ 1000 mg
- 1 × Replaceable needle
Disclaimer: Supplied strictly for laboratory, educational and research use only. Not for medical, performance or therapeutic use. This product is not registered as a medicine or dietary supplement. All handling, storage and disposal must comply with applicable laws and institutional standards.
NAD+ 1000mg
- Brand: The Clinic
- Product Code: NAD-1k
- Reward Points: 55
- Availability: In Stock
Available Options
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